Lots of good, thought-provoking stuff in this 2005 commencement speech by David Foster Wallace.  The following section especially jumped out at me knowing how Wallace would eventually kill himself a few years later:

"It is not the least bit coincidental that adults who commit suicide with firearms almost always shoot themselves in: the head. They shoot the terrible master. And the truth is that most of these suicides are actually dead long before they pull the trigger."